Technical Proceedings of the 2010 NSTI Nanotechnology Conference & Expo - Nanotech 2010
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Nanotech 2010 Vol. 3
Chapter 1: Bio Sensors, Diagnostics & Imaging
Copper 64-Cu nanoparticles in multimodal imaging of carotid artery disease
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| Authors: | R. Sharma, A. Sharma |
| Affiliation: | Florida State University, US |
| Pages: | 70 - 72 |
| Keywords: | Cu-64 nanoparticle, atherosclerosis, bioimaging, multimodal imaging |
| Abstract: | Nanoparticle based hybrid imaging by MRI, PET-CT and Fluorescent reflectance techniques are emerging in imaging carotid artery disease. 64Cu-TNP is detectable by MRI and PET-CT. A trimodality reporter 64Cu-TNP is a derivatization product made of: 1. the chelator DTPA attached with radiotracer 64Cu and iron oxide core in center provides contrast in MRI imaging(T2, T2*, or steady-state free-precession sequences); 2. fluorochrome attached with 64Cu-TNP is used for fluorescence imaging, including fluorescence microscopy, flow cytometry, and fluorescence-mediated tomography; 3. crosslinked aminated polysaccharide coating provides the biocompatibility and determines the blood half-life and provides linker for attachment of tracers and potentially affinity ligands. The novelty of 64-Cu nanoparticle is that it provides structural, molecular and physiological information same time in carotid artery disease. Other possible techniques based 64-Cu nanoparticles are possible multiple contrast magnetic resonance imaging, susceptibility weighted imaging, positron emission tomography, nanoparticle based imaging, computer tomography, fluorescent based imaging, and fluorescent microscopy but not confirmed yet. |
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