Technical Proceedings of the 2010 NSTI Nanotechnology Conference & Expo - Nanotech 2010
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Nanotech 2010 Vol. 3
Chapter 5: Drug & Gene Delivery
Novel nanostructured drug delivery technology to enhance bioavailability, increase solubility and drug loading
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| Authors: | G. Heltovics, Zs. Ötvös, G. Filipcsei, F. Darvas |
| Affiliation: | NanGenex Inc., HU |
| Pages: | 338 - 341 |
| Keywords: | drug nanoparticles, increase solubility, enhanced bioavailability |
| Abstract: | In the presentation we will discuss the perspectives and pharmacokinetic benefits of the nanosized active molecules over the parent active molecules. The bioavailability of reference and nanosized drug was determined after oral administration (30 mg/kg) in fasted state at Sprague-Dawley rats using international standard protocols. Nanosized drug had an AUC15-360 min value of 6412 g∙min/ml while this value after reference treatment was 940.1 g∙min/ml. The ratio of the two AUC values (AUC15-360 min (nanosized) / AUC15-360 min (reference)) was 6.82. |
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