Technical Proceedings of the 2010 NSTI Nanotechnology Conference & Expo - Nanotech 2010
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Nanotech 2010 Vol. 3
Chapter 6: Cancer Nanotechnology
Doxorubicin-loaded and Antibody-Conjugated Liposome-QD Hybrid Vesicles for Targeted Cancer Therapy and Imaging
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| Authors: | B.W. Tian, W.T. Al-Jamal, M. Stuartb, K. Kostarelos |
| Affiliation: | The School of Pharmacy, University of London, UK |
| Pages: | 380 - 381 |
| Keywords: | multimodal vesicles, targeted cancer therapy, imaging, MUC1 |
| Abstract: | In this study, we report the engineering of multimodal Liposome-QD hybrids (L-QD) for cancer imaging and therapy. L-QD hybrids were loaded with doxorubicin (Dox) using the osmotic gradient technique, achieving high encapsulation efficiency comparable to liposome alone. Structural elucidation using cryogenic electron microscopy (cryo-EM) clearly showed that QD were incorporated in the lipid bilayer and Dox crystals were encapsulated into the liposome aqueous core. Furthermore, the surface of Dox-loaded hybrids were functionalized with anti-MUC-1 antibody for active targeting, using the post-insertion technique.MUC-1 antibody-targeted L-QD hybrids encapsulating doxorubicin are thought to constitute a potential multimodal system for the simultaneous delivery of therapeutic and diagnostic agents to cancer cells in vitro and in vivo. |
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