Technical Proceedings of the 2010 NSTI Nanotechnology Conference & Expo - Nanotech 2010
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Nanotech 2010 Vol. 3
Chapter 6: Cancer Nanotechnology
Nanocarriers for Cancer Therapy
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| Authors: | V. Vergaro, Z. Zheng, X. Zheng, Y.M. Lvov, G. Giovinazzo, A. Santino, R. Cingolani, R. Rinaldi, S. Leporatti |
| Affiliation: | National Nanotechnology Laboratory (NNL) of CNR-INFM, IT |
| Pages: | 393 - 394 |
| Keywords: | nanocarriers, nanocolloids, nanotubes, oleosomes, cancer, nanotechnology |
| Abstract: | Drug nano-colloids encapsulated by combination of layer by layer (LbL) techniques and ultrasonication, phytochemical encapsulated-artificial oleosomes and drug-loading clay nanotubes have been uptaken by neoplastic cells. Morpho- mechanical changes induced by such nanocarriers in living cancer cells have been detected by a combination of high resolution optical and scanning force microscopy techniques.Elasticity, which is considered a relevant marker of vitality and neoplastic invasiveness of cancer cells, has been quantified by Force Mapping Mode.The Young’s modulus of living treated cells is significantly modified in a time- and drug- carrier concentration-dependent manner as a consequence of modifications in cytoskeletal and contractile filament organization observed by selective fluorescent stainings. |
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