Technical Proceedings of the 2010 NSTI Nanotechnology Conference & Expo - Nanotech 2010
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Nanotech 2010 Vol. 3
Chapter 6: Cancer Nanotechnology
Combining gene therapy and nanomedicine to enhance the therapeutic potential of T cells
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| Authors: | Y. Choi, H. Torikai, D.Y. Lee, Z. Li, D. Lo, G. Qin, C.H. Tung, E. Tasciotti, R. Raphael, S.L. Biswal, S. Ang, D.A. Lee, K.C. Li, L.J.N. Cooper |
| Affiliation: | M.D. Anderson Cancer Center, US |
| Pages: | 376 - 379 |
| Keywords: | electroporation, indium, gold nanoparticle, T cell |
| Abstract: | we have developed a high throughput electroporator (HiTE) to manipulate large numbers (~10^9) of T cells ex vivo for clinical uses. HiTE is designed to electro-transfer RNA species to redirect T-cell specificity and gold nanoparticles (Au-NPs) that can be functionalized to enhance T-cell biology. By introducing both transgenes and Au-NPs we are generating T cells that can be rapidly modified to act as a drug-delivery system for targeted therapy of lung cancer. |
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