An IUBMB/ IUPAB Advanced School and Workshop

Protein-Protein and Protein-Membrane interaction:
experimental and theoretical approaches

October 22nd-26th, 2018

An IUBMB/ IUPAB Advanced School and Workshop

Protein-Protein and Protein-Membrane interaction:
experimental and theoretical approaches

October 22nd-26th, 2018

An IUBMB/ IUPAB Advanced School and Workshop

Protein-Protein and Protein-Membrane interaction:
experimental and theoretical approaches

October 22nd-26th, 2018

Welcome!

Biophysical experimental methods and biomolecular simulations are crucial for understanding protein-protein and protein-membrane interactions. The School is oriented to postgraduates and young researchers interested in fundamental knowledge on the state of the art of experimental and theoretical studies of protein-protein and protein-membrane interactions, essentials for biotechnology and bio-nanosciences. The main goal of the course is to allow understanding and incorporating these topics into participants´ research and teaching activities and share their experiences with lecturers and peers. The course has been conceived in 18 lectures in the mornings and exchange sessions during afternoons between lecturers and students. Scientific discussions between students and lecturers will be encouraged in other spaces as well.

Application

Attendance of Young Postgraduates

It is foreseen that around 50 young scientists from different geographical regions could attend the Advanced School. They will be partially or completely financially supported by IUBMB and IUPAB grants as well as other sponsors. Based on candidate´s age-Curriculum Vitae, area of professional research/interest, and a letter explaining her/his interest in the course, the academic committee of the course will decide the acceptance of candidates to support their participation. Some Cuban young scientists will be also supported by the National Cuban Societies of Physics and Chemistry as well as the Center for Molecular Immunology (CIM), The Center for Genetic Engineering and Biotechnology (CIGB), the Center for Drug Research and Development (CIDEM) and the University of Havana (UH). The attendance of young scientist will be partially or totally supported according to the candidate conditions and final budget granted.

This course will validate credits for the PosLatAm program!

To our successful applicants we will provide:

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Deadline for Applications

Deadline for applications has passed. The scientific committee is analyzing all the applications. We will let all the applicants know as soon as we made the final decision.

Plese, feel free to contact us if you need any information. Send an e-mail to advanced.school18@gmail.com with copy to advanced.school18@fbio.uh.cu with your concern. We email you as soon as possible.

Organizers and appointment place

Image

Dr. Carlos Álvarez

Main Organizer

  • Past-Secretary, Cuban Section of Biochemistry and Molecular Biology.
  • Member of the Cuban Academy of Sciences.
  • Center for Protein Studies, Faculty of Biology , 25 St. % I and J. Vedado.
  • University of Havana.
    Cuba.
    FAX:+537 8321321
    calvarez@fbio.uh.cu

    Image

    Dr. Pedro A. Valiente

    Main Organizer

  • Course organizer.
  • Center for Protein Studies, Faculty of Biology , 25 St. % I and J. Vedado.

  • University of Havana.
    Cuba.
    FAX:+537 8321321
    valiente@fbio.uh.cu

    Image

    Dr. Isel Pascual

    Main Organizer

  • Course organizer.
  • Center for Protein Studies, Faculty of Biology , 25 St. % I and J. Vedado.
  • University of Havana.
    Cuba.
    FAX:+537 8321321
    isel@fbio.uh.cu

    Image

    Dr. Kalet León

    Co-Organizer

  • General Director for Research and Development at INIM.
  • Member of the Cuban Academy of Sciences.
  • Center for Molecular Inmunology.
    Havana.
    Cuba.
    kalet@cim.sld.cu

    Meeting Place

    Hotel

    Ocean Vista Azul Varadero

    View More

    Ocean Vista Azul Hotel has basic lecturing facilities as well as perfect locations for poster presentation and discussion, excellent and economic accommodation, as well as an exceptional natural environment to be used as venue of the School. Varadero Beach has an international airport and all communications with Havana are excellent. Besides, there are previous experiences of other scientific meetings successfully held in this location.

    Speakers and Lectures

    Biomolecular Simulations

    Scientific Interest

    Protein-Membrane Interaction. Computational State-of-Art Methods to Understand Biological Processes in Membranes

    Dr. Valentina Corradi

    Center for Molecular Simulation. Department of Biological Sciences. University of Calgary
    vcorradi@ucalgary.ca

    Title of the Conference

    Lipid-Protein Interplay Seen Through Computer Simulations

    Scientific Interest

    Non-Equilibrium Thermodynamics, Ion-Selectivity Mechanism, Ion Channel Blockers

    Dr. Sergei Yu Noskov

    Center for Molecular Simulation. Department of Biological Sciences. University of Calgary
    snoskov@ucalgary.ca

    Title of the Conference

    Tubulin and Outer Mitochondrial Membrane Interactions: Window into Structural Mechanisms Controlling Metabolite Flux

    Scientific Interest

    Development of Coarse Graining and Mesoscopic Methodologies to Understand Biological Processes

    Dr. Siewert Jan Marrink

    Department of Biophysical Chemistry Groningen Biomolecular Sciences and Biotechnology Institute. Faculty of Science and Engineering. University of Groningen. Netherlands
    s.j.marrink@rug.nl

    Title of the Conference

    Computational Microscopy of Complex Cellular Membranes

    Scientific Interest

    Computational Electrophisiology. Molecular Simulations of Membrane Protein Function

    Dr. Ulrich Zachariae

    The Discovery Centre for Translational and Interdisciplinary Research College of Life Sciences. University of Dundee
    u.zachariae@dundee.ac.uk

    Title of the Conference

    Computational Insights of Ion Selectivity in K+ Voltage-Gated Channels

    Scientific Interest

    Computational Biology, Study of Enzyme Function, Functional Genomics, Drug Discovery

    Dr. Mary Jo Ondrechen

    Department of Chemistry and Chemical Biology, Northeastern University
    m.ondrechen@neu.edu

    Title of the Conference

    Role of Protein Electrostatics in Function and Recognition

    Scientific Interest

    Computational State-of-Art Methods to Understand Protein-Protein Interaction

    Dr. Pedro A. Valiente

    Center for Protein Studies, Faculty of Biology, University of Havana, Cuba
    valiente@fbio.uh.cu

    Title of the Conference

    Understanding the Pore-Formation Mechanism of Actinoporins

    Experimental Approaches

    Scientific Interest

    Electronic Paramagnetic Resonance Spectroscopy (EPR). Interactions Between Biologically-Relevant Molecules.Interactions Between Biologically Relevant Molecules

    Dr. Antonio Jose da Costa-Filho

    Physics Dep, FFCLRP-USP
    ajcosta.ffclrp.usp@gmail.com

    Title of the Conference

    There are Always Two Sides to a Lipid-Protein Story

    Scientific Interest

    NMR. Potein-Protein interaction NMR

    Dr. Clemens Anklin

    Bruker BioSpin NMR Applications & Training Biomolecular NMR
    clemens.anklin@bruker.com

    Title of the Conference

    NMR Experiments for the Characterization of Complexes Between Proteins and Proteins and Other Molecules

    Scientific Interest

    Calorimetry. Biophysics of Proteins and
    Ligand-Protein Interactions

    Dr. Juan M. Ruso

    Department of Applied Physics University of Santiago de Compostela (USC), Spain
    juanm.ruso@usc.es

    Title of the Conference

    Microcalorimetry Tools in Biophysics.
    Biophysics: Biology Redesigned

    Scientific Interest

    Small Angle X Ray Scattering (SAXS). Protein-protein and Protein Membrane Interaction. Biophysics of Membranes

    Dr. Rosangela Itri

    Departamento de Física Aplicada Instituto de Física. Cidade Universitária. São Paulo. Brasil
    itri@if.usp.br

    Title of the Conference

    Protein-Protein and Protein Membrane Interaction by SAXS

    Scientific Interest

    Circular Dichroism Spectroscopic Studies of Proteins, Development of Methods and Bioinformatics Tools for Analysis and Interpretation of CD Data, Studies of the Structure and Function of Membrane Proteins

    Dr. Bonnie A. Wallace

    Birkbeck College, University of London, UK
    b.wallace@mail.cryst.bbk.ac.uk

    Title of the Conference

    Measurement, Analyses and Interpretation of Circular Dichroism Spectra

    Scientific Interest

    Protein-Membrane Interaction
    Pore forming toxins

    Dr. Carlos Álvarez

    Center for Protein Studies, Faculty of Biology, University of Havana, Cuba
    calvarez@fbio.uh.cu

    Title of the Conference

    Biochemical and Biophysical Strategies to Understand Pore Formation by Sticholysins

    Scientific Interest

    Peptidases and Peptidases Inhibitors of Biomedical Relevance

    Dr. Isel Pascual

    Center for Protein Studies, Faculty of Biology, University of Havana, Cuba
    isel@fbio.uh.cu

    Title of the Conference

    Methods for the Study of Peptidase:Inhibitor Interactions

    Scientific Interest

    Lipidomics. Biophysics of Membranes. Biophysics of Membranes

    Dr. Manuel Prieto

    Center for Molecular Physical-Chemistry, Lisbon, Portugal
    manuel.prieto@ist.utl.pt

    Title of the Conference

    Application of Spectroscopic Techniques to Study the Interaction of Different Compounds with Model Membrane Systems

    Scientific Interest

    Membrane Biophysics. Interaction of Bio-active Molecules with Model Lipid Membranes

    Dr. María Laura Fanani

    Dpto. Química Biológica Ranwel Caputto, Facultad de Ciencias Químicas, Univ. Nacional de Córdoba y CIQUIBIC- Consejo Nacional de Investigaciones Científicas y Técnicas de Argentina (CONICET)
    lfanani@gmail.com

    Title of the Conference

    The Effect of Phospholipase Action and Bioactive Peptides on Lipid Membranes

    Scientific Interest

    Membrane Transport Proteins, Nitric Oxide Signaling and Regulation, Ion Transport ATPases, Enzyme Kinetics and Thermodynamics

    Dr. R. Daniel Peluffo

    Professor of Biophysics, IUPAB's Councillor, Director, Group of Biophysical Chemistry, Chairman, Dept. of Biological Sciences, CENUR Litoral Norte, UdelaR Rivera 1350 (CP: 50000) Salto, Uruguay
    dpeluffo@unorte.edu.uy

    Title of the Conference

    Cationic Amino Acid Transporters and Nitric Oxide Synthases: a Story of Two Neighboring Proteins

    Scientific Interest

    Structural Biology and Circular Dichroism Spectroscopy, Development of Bioinformatics Tools to Support the Interpretation and Analysis of CD Data and Spectra

    Dr. Robert W. Janes

    Queen Mary University of London, UK

    Workshop Topic

    Bioinformatics and Analyses Tools for Circular Dichroism Spectra

    Program

    Schedule

    Morning

    09:00AM-12:30PM

    Travel from Havana to Varadero

    lunch

    1:00PM Lunch02:30PM

    lunch

    Afternoon

    02:30PM-06:00PM
    Registration
    Welcome Words
    Carlos Álvarez
    Opening Lecture
    Kalet León
    lunch

    06:30PM Dinner10:00PM

    lunch

    Nigth

    09:00PM-...

    Free Time

    Morning

    Chairpersons: Maday Alonso

    09:00AM-09:45AM Lecture

    Clemens Anklin

    NMR Experiments for the Characterization of Complexes Between Proteins and Proteins and Other Molecules

    Cycling 09:50AM-10:35AM Lecture

    Keith Moffat

    Time-Resolved X-ray Crystallography of Signaling Photoreceptors: How Does the Isomerization Really Occurs?

    Cycling 10:40AM-11:00AM

    Break

    11:00AM-11:45AM Lecture

    Bonnie Wallace

    Measurement, Analyses and Interpretation of Circular Dichroism Spectra

    11:50AM-12:35M Lecture

    Juan M. Ruso

    Microcalorimetry Tools in Biophysics. Biophysics: Biology Redesigned

    lunch

    1:00PM Lunch02:30PM

    lunch

    Afternoon

    Chairpersons: Juan M. Ruso

    2:30PM-3:15PM Lecture

    Isel Pascual

    Methods for the Study of Peptidase:
    Inhibitor Interactions

    3:30PM-6:00PM Interaction with students:
    Exchange about techniques
    Exchange on collaboration
    lunch

    06:00PM Dinner10:00PM

    lunch

    Nigth

    Chairpersons: Vivian Montero, Mario E. Valdés

    6:00PM-10:00PM

    Flying Poster Session

    Morning

    Chairpersons: María E. Lanio

    09:00AM-09:45AM Lecture

    Manuel Prieto

    Application of Spectroscopic Techniques to Study the Interaction of Different Compounds with Model Membrane Systems

    Cycling 09:50AM-10:35AM Lecture

    Rosangela Itri

    Protein-Protein and Protein Membrane Interaction by SAXS

    Cycling 10:40AM-11:00AM

    Break

    11:00AM-11:45AM Lecture

    Laura Fanani

    The Effect of Phospholipase Action and Bioactive Peptides on Lipid Membranes

    11:50AM-12:35M Lecture

    Antonio da Costa Filho

    There are Always Two Sides to a Lipid-Protein Story

    lunch

    1:00PM Lunch02:30PM

    lunch

    Afternoon

    Chairpersons: Rosangela Itri

    2:30PM-6:00PM Workshop

    Robert Janes

    Bioinformatics and Analyses Tools for Circular Dichroism Spectra

    lunch

    06:00PM Dinner10:00PM

    lunch

    Nigth

    Chairpersons: Isabel F. Pazos, Karina García

    6:00PM-10:00PM

    Flying Poster Session

    Morning

    Chairpersons: Pedro A. Valiente

    09:00AM-09:45AM Lecture

    R. Daniel Peluffo

    Cationic Amino Acid Transporters and Nitric Oxide Synthases: a Story of Two Neighboring Proteins

    Cycling 09:50AM-10:35AM Lecture

    Siewert Jan Marrink

    Computational Microscopy of Complex Cellular Membranes

    Cycling 10:40AM-11:00AM

    Break

    11:00AM-11:45AM Lecture

    Ulrich Zachariae

    Computational Insights of Ion Selectivity in K+ Voltage-Gated Channels

    11:50AM-12:35M Lecture

    Mary Jo Ondrechen

    Role of Protein Electrostatics in Function and Recognition

    lunch

    1:00PM Lunch02:30PM

    lunch

    Afternoon

    Chairpersons: Manuel Prieto

    2:30PM-3:15PM Lecture

    Carlos Álvarez

    Biochemical and Biophysical Strategies to Understand
    Pore Formation by Sticholysins

    3:30PM-6:00PM Lectures Meeting to Decide Awardees
    Exchange about techniques
    Exchange on collaboration
    lunch

    06:00PM Dinner10:00PM

    lunch

    Nigth

    Poster Award Ceremony

    6:00PM-10:00PM

    Farewell Dinner

    Concluding Remarks

    Morning

    Chairpersons: Laura Fanani

    09:00AM-09:45AM Lecture

    Valentina Corradi

    Lipid-Protein Interplay Seen Through Computer Simulations

    Cycling 09:50AM-10:35AM Lecture

    Sergei Yu Noskov

    Tubulin and Outer Mitochondrial Membrane Interactions: Window into Structural Mechanisms Controlling Metabolite Flux

    Cycling 10:40AM-11:00AM

    Break

    11:00AM-11:45AM Lecture

    Pedro A. Valiente

    Understanding the Pore-Formation Mechanism of Actinoporins

    11:50AM-12:35M Lecture

    Anne Simon Moffat

    Winning Support for your Science: Clear Writing for Colleagues and Everybody Else

    lunch

    12:30PM Lunch02:30PM

    lunch

    Afternoon

    02:30PM-06:00PM

    Departure to Havana

    Comments

    "The advanced school of 2015 had extremely good quality, with high-level professors and good participation of the students. To place the session of poster at night was a great idea. I think the competition of posters was very productive. So, it should keep on!"

    Dr. Karina García/ Head of Biology Systems Group/ CIM

    "Now back at home I realized how many beautiful memories I will retain from Cuba. I was really impressed with the preparation and active participation of the students not only during the conference sessions but also during our chats on coffee breaks or dinners. I am glad to have been part of this school and hope that the support will be retained for future editions - students deserve this type of effort."

    Dr. José A Gavira/ Laboratory of Crystallographic Studies IACT, CSIC-University of Granada/ Spain

    "At the end of the 2015 IUBMB Advanced School, students and lecturers were surveyed in order to get their views. The following general comments are based on their opinions:
    i. High scientific level of teachers, ii. Highly participative and well prepared students, iii. Active educational activities based on questions-answers and exchange among participants, iv. poster presentation, its defense, and prizegiving to the best contributions"

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